TH5427 (hydrochloride)

TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM) . TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].

Product Specifications

CAS Number

[2253744-57-7]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th5427-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O

Molecular Formula

C20H21Cl3N8O3

Molecular Weight

527.79

References & Citations

[1]Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10 (1) :5050]. Nat Commun. 2018;9 (1) :250. Published 2018 Jan 17.