TH5427 (hydrochloride)
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM) . TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].
Product Specifications
CAS Number
2253744-57-7
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th5427-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O
Molecular Formula
C20H21Cl3N8O3
Molecular Weight
527.79
References & Citations
[1]Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10 (1) :5050]. Nat Commun. 2018;9 (1) :250. Published 2018 Jan 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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