TH5427 (hydrochloride)
TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM) . TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells[1].
Product Specifications
CAS Number
2253744-57-7
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th5427-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.O=C(N1C)N(C)C2=C(N(CC3=NN=C(C4=CC=C(Cl)C(Cl)=C4)O3)C(N5CCNCC5)=N2)C1=O
Molecular Formula
C20H21Cl3N8O3
Molecular Weight
527.79
References & Citations
[1]Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10 (1) :5050]. Nat Commun. 2018;9 (1) :250. Published 2018 Jan 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
042286-ML490 100 µL
SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 490) discontinued
Sign In for Pricing
View Details 
