BRD5631

BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway. BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production[1].

Product Specifications

CAS Number

[2446154-91-0]

UNSPSC

12352005

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Cancer-programmed cell death

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/brd5631.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C2C(C(N(C[C@@H](OC)[C@@H](C)CN[C@@H](C)CO2)C)=O)=C1)C3=CC=C(C4=CC=CC=C4)C=C3

Molecular Formula

C30H35N3O4

Molecular Weight

501.62

References & Citations

[1]Kuo SY, et al. Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics. Proc Natl Acad Sci U S A. 2015 Aug 4;112 (31) :E4281-7.