BRD1991
Product Specifications
UNSPSC Description
BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death[1].
Target Antigen
Bcl-2 Family; Beclin1
Type
Reference compound
Related Pathways
Apoptosis;Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd1991.html
Solubility
10 mM in DMSO
Smiles
CN1C2=CC=CC=C2C3=C1C(N(C(CO)C)CC(C)C(CN(C(C4=CC(Cl)=CC(Cl)=C4)=O)C)OCC5=CC=CC=C53)=O
Molecular Weight
608.55
References & Citations
[1]Wei-Chung Chiang, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018 Aug 17;13(8):2247-2260.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125191/BRD1991-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125191/
Clinical Information
No Development Reported
CAS Number
2235468-02-5
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