BRD1991
BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death[1].
Product Specifications
CAS Number
[2235468-02-5]
UNSPSC
12352005
Target
Bcl-2 Family; Beclin1
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/brd1991.html
Solubility
10 mM in DMSO
Smiles
CN1C2=CC=CC=C2C3=C1C(N(C(CO)C)CC(C)C(CN(C(C4=CC(Cl)=CC(Cl)=C4)=O)C)OCC5=CC=CC=C53)=O
Molecular Formula
C33H35Cl2N3O4
Molecular Weight
608.55
References & Citations
[1]Wei-Chung Chiang, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018 Aug 17;13 (8) :2247-2260.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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