Galiellalactone

Galiellalactone is a is a small non-toxic and non-mutagenic fungal metabolite, a selective inhibitor of STAT3 signaling, with an IC50 of 250-500 nM. Galiellalactone can be used to research castration-resistant prostate cancer[1][2][3].

Product Specifications

CAS Number

[133613-71-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

STAT

Type

Natural Products

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/galiellalactone.html

Purity

Solubility

10 mM in DMSO

Smiles

O=C1C2=C[C@@H](C)C[C@@]3([H])CC[C@@]([C@@]23O)([H])O1

Molecular Formula

C11H14O3

Molecular Weight

194.23

Precautions

H315, H319

References & Citations

[1]Hellsten R, et, al. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. Prostate. 2008 Feb 15; 68 (3) : 269-80.|[2]Doncow DN, et, al. Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J Biol Chem. 2014 Jun 6; 289 (23) : 15969-78.|[3]Weidler M, et, al. Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 2000 Oct 27; 484 (1) : 1-6.