AZ12253801
AZ12253801 is an ATP-competitive IGF-1R tyrosine kinase inhibitor that shows ～10-fold selectivity over the insulin receptor. AZ12253801 inhibits IGF-1R-driven proliferation in 3T3 mouse fibroblasts (transfected with human IGF-1R) with an IC50 of 17 nmol/L. The IC50 for epidermal growth factor receptor (EGFR) -driven proliferation is 440 nmol/L. Anti-tumor activity.
Product Specifications
CAS Number
851432-37-6
UNSPSC
12352005
Target
IGF-1R
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az12253801.html
Solubility
10 mM in DMSO
Smiles
[H][C@](CCC1)(C2=CC(C3=CC=CC=N3)=NO2)N1C4=NC(C)=CC(NC5=NNC(C)=C5)=N4
Molecular Formula
C21H22N8O
Molecular Weight
402.45
References & Citations
[1]https://aacrjournals.org/cancerres/article/70/16/6412/559448/Type-1-Insulin-like-Growth-Factor-Receptor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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