SMI 6860766
SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1].
Product Specifications
CAS Number
433234-16-3
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/smi-6860766.html
Purity
99.82
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1)/C=C/NC2=CC=C(Br)C=C2Cl
Molecular Formula
C15H11BrClNO
Molecular Weight
336.61
References & Citations
[1]Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond) . 2015 May;39 (5) :782-90.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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