SMI 6860766

SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1].

Product Specifications

CAS Number

[433234-16-3]

UNSPSC

12352005

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/smi-6860766.html

Purity

99.82

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1)/C=C/NC2=CC=C(Br)C=C2Cl

Molecular Formula

C15H11BrClNO

Molecular Weight

336.61

References & Citations

[1]Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond) . 2015 May;39 (5) :782-90.