ARN14988
ARN14988 is a potent inhibitor of acid ceramidase (ACDase) (IC50=12.8 nM for the human enzyme) [1].
Product Specifications
CAS Number
1502027-70-4
UNSPSC
12352005
Target
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arn14988.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C1=O)C(C(Cl)=CN1C(NCCCCCC)=O)=O)OCC(C)C
Molecular Formula
C16H24ClN3O5
Molecular Weight
373.83
References & Citations
[1]Realini N, et al. Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. J Biol Chem. 2016 Jan 29;291 (5) :2422-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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