Arylsulfonamide 64B

Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF) . Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model[1].

Product Specifications

CAS Number

[1342890-83-8]

Product Name Alternative

HIF inhibitor 64B

UNSPSC

12352005

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/arylsulfonamide-64b.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(OC)C(OC)=C1)(N(C2CCC2)CC3=CC=C4C(C=CC(C)(C)O4)=N3)=O

Molecular Formula

C23H28N2O5S

Molecular Weight

444.54

References & Citations

[1]Dong L, Y, et al. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma. Clin Cancer Res. 2019;25 (7) :2206-2218.