Arylsulfonamide 64B
Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF) . Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model[1].
Product Specifications
CAS Number
1342890-83-8
Product Name Alternative
HIF inhibitor 64B
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arylsulfonamide-64b.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(OC)C(OC)=C1)(N(C2CCC2)CC3=CC=C4C(C=CC(C)(C)O4)=N3)=O
Molecular Formula
C23H28N2O5S
Molecular Weight
444.54
References & Citations
[1]Dong L, Y, et al. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma. Clin Cancer Res. 2019;25 (7) :2206-2218.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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