7DG
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1].
Product Specifications
CAS Number
[26927-01-5]
Product Name Alternative
7-Desacetoxy-6,7-dehydrogedunin
UNSPSC
12352005
Hazard Statement
H302
Target
PERK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7dg.html
Purity
98
Solubility
10 mM in DMSO
Smiles
O=C1O[C@@H](C2=COC=C2)[C@]3(C)CC[C@@]4([H])[C@](C=C[C@@]5([H])C(C)(C)C(C=C[C@@]54C)=O)(C)[C@@]36[C@@H]1O6
Molecular Formula
C26H30O5
Molecular Weight
422.51
Precautions
H302
References & Citations
[1]Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9 (6) :398-405. |[2]Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288 (22) :6365-6391.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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