KSP-IA
KSP-IA (compound 17) is a potent kinesin spindle protein (KSP) inhibitor with an IC50 value of 3.6 nM. KSP-IA inhibits cell mitosis[1].
Product Specifications
CAS Number
639074-49-0
UNSPSC
12352005
Target
Kinesin; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ksp-ia.html
Solubility
10 mM in DMSO
Smiles
CC(C)[C@H](N)C(N1[C@H](C2=CC=CC=C2)C=C(C3=CC(F)=CC=C3F)C1)=O
Molecular Formula
C21H22F2N2O
Molecular Weight
356.41
References & Citations
[1]Fraley ME, et, al. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2006 Apr 1;16 (7) :1775-9.|[2]Fraley ME, et, al. Kinesin spindle protein (KSP) inhibitors. Part 2: the design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP. Bioorg Med Chem Lett. 2006 Apr 1;16 (7) :1775-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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