(S) -C33
(S) -C33 is a potent and selective PDE9 (phosphodiesterase-9) inhibitor, with an IC50 of 11 nM. (S) -C33 can be used for central nervous system diseases and diabetes research[1].
Product Specifications
CAS Number
2066488-39-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-c33.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[C@H](C4=CC=C(Cl)C=C4)C)N1
Molecular Formula
C18H20ClN5O
Molecular Weight
357.84
Precautions
H302, H315, H319
References & Citations
[1]Huang M, Shao Y, Hou J, et al. Structural Asymmetry of Phosphodiesterase-9A and a Unique Pocket for Selective Binding of a Potent Enantiomeric Inhibitor. Mol Pharmacol. 2015;88 (5) :836-845.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE2; PDE4; PDE5; PDE9
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