Poloppin
Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM) . Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].
Product Specifications
CAS Number
683808-78-8
UNSPSC
12352005
Target
Autophagy; Mitosis; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/poloppin.html
Solubility
10 mM in DMSO
Smiles
O=C(O)CCC1=CC=C(C2=CC=C(Br)C=C2)N1C3=CC=CC=C3C(F)(F)F
Molecular Formula
C20H15BrF3NO2
Molecular Weight
438.24
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
MMP9 Recombinant Rabbit Monoclonal Antibody (BF555)