ENMD-1068
ENMD-1068 is a selective protease-activated receptor 2 (PAR2) antagonist. ENMD-1068 reduces hepatic stellate cell activation and collagen expression by inhibiting TGF-β1/Smad signaling. ENMD-1068 also inhibits the proliferation of endometrial cells and induces apoptosis of epithelial cells in the lesion. ENMD-1068 can be used in the study of endometriosis and liver fibrosis[1][2].
Product Specifications
CAS Number
789488-77-3
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/enmd-1068.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCN(C(CC(C)C)=O)CC1)CCCCCN
Molecular Formula
C15H29N3O2
Molecular Weight
283.41
Precautions
P264-P270-P330-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
Frequently Asked Questions
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