LIT-001 (free base)
LIT-001 free base is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM) . LIT-001 free base improves social interaction in a mouse model of autism[1].
Product Specifications
CAS Number
2245072-20-0
UNSPSC
12352005
Target
Oxytocin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lit-001-free-base.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@H](C(N(C)C)=S)CCC1)NCC2=CC=C(C(N3CC4=C(N(C)N=C4)NC5=CC=CC=C35)=O)C=C2C
Molecular Formula
C28H33N7O2S
Molecular Weight
531.67
References & Citations
[1]Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61 (19) :8670-8692.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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