Divin
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm[1][2][3].
Product Specifications
CAS Number
1443321-11-6
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/divin.html
Purity
95.65
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(N/N=C/C1=C2C=CC=CC2=CC=C1O)CCN3C4=CC=CC=C4N=C3C
Molecular Formula
C22H20N4O2
Molecular Weight
372.42
References & Citations
[1]Maoquan Zhou, et al. Structure-activity studies of divin: an inhibitor of bacterial cell division. ACS Med Chem Lett. 2013 Sep 12;4 (9) :880-885.|[2]Ye-Jin Eun, et al. Divin: a small molecule inhibitor of bacterial divisome assembly. J Am Chem Soc. 2013 Jul 3;135 (26) :9768-76.|[3]Thiago M A Santos, et al. Small Molecule Chelators Reveal That Iron Starvation Inhibits Late Stages of Bacterial Cytokinesis. ACS Chem Biol. 2018 Jan 19;13 (1) :235-246.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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