SS148
SS148 is a dual inhibitor of nsp14/nsp16 MTase. SS148 significant inhibits nsp10–nsp16 with an IC50 of 1.2 μM[1][2].
Product Specifications
CAS Number
1985669-27-9
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ss148.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CN(C2=NC=NC(N)=C21)[C@@H]3O[C@H](CSCC[C@@H](C(O)=O)N)[C@@H](O)[C@H]3O
Molecular Formula
C16H20N6O5S
Molecular Weight
408.43
References & Citations
[1]Nigam A, et al. Drug Discovery in Low Data Regimes: Leveraging a Computational Pipeline for the Discovery of Novel SARS-CoV-2 Nsp14-MTase Inhibitors. bioRxiv [Preprint]. 2023 Nov 13:2023.10.03.560722.|[2]Klima M, et al. Crystal structure of SARS-CoV-2 nsp10-nsp16 in complex with small molecule inhibitors, SS148 and WZ16. Protein Sci. 2022 Sep;31 (9) :e4395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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