JI130

JI130 (JI051 derivative) is a stabilizer for the Hes1-PHB2 interaction. JI130 inhibits the ability of Hes1 to repress transcription. JI130 significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for managing pancreatic cancer[1].

Product Specifications

CAS Number

[2234271-86-2]

UNSPSC

12352005

Target

Notch

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ji130.html

Purity

99.41

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C

Molecular Formula

C23H24N2O3

Molecular Weight

376.45

References & Citations

[1]Amelie Perron, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293 (21) :8285-8294.