K-Ras (G12C) inhibitor 9
K-Ras (G12C) inhibitor 9 is an allosteric inhibitor of the K-Ras (G12C) [1].
Product Specifications
CAS Number
[1469337-91-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k-ras-g12c-inhibitor-9.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
C=CS(=O)(NC1CCN(C(CNC2=CC(I)=C(Cl)C=C2OC)=O)CC1)=O
Molecular Formula
C16H21ClIN3O4S
Molecular Weight
513.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Ostrem JM, et al. K-Ras (G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503 (7477) :548-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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