4'-Hydroxytamoxifen

4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells[1].

Product Specifications

CAS Number

[82413-23-8]

UNSPSC

12352005

Target

Drug Metabolite; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-hydroxytamoxifen-a.html

Purity

99.2

Solubility

DMF : 20 mg/mL (ultrasonic; warming)

Smiles

CC/C(C1=CC=C(C=C1)O)=C(C2=CC=C(C=C2)OCCN(C)C)\C3=CC=CC=C3

Molecular Formula

C26H29NO2

Molecular Weight

387.51

References & Citations

[1]Cuevas ME, et, al. In vitro cytotoxicity of 4'-OH-tamoxifen and estradiol in human endometrial adenocarcinoma cells HEC-1A and HEC-1B. Oncol Rep. 2015 Jan;33 (1) :464-70.