12 (S) -HETE

12 (S) -HETE is the 12-lipoxygenase metabolite of arachidonic acid and has a mitogenic effect on cancer cell proliferation. 12 (S) -HETE induces tyrosine phosphorylation of cellular proteins, promotes ERK and P38 MAPK phosphorylation, increases DNA synthesis, and stimulates the proliferation of pancreatic cancer cells[1][2].

Product Specifications

CAS Number

[54397-83-0]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

DNA/RNA Synthesis; ERK; p38 MAPK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/12-s-hete.html

Concentration

312.04 μM * 1 mL in Ethanol

Purity

99.10

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H32O3

Molecular Weight

320.47

Precautions

H225, H319

References & Citations

[1]Ding XZ, et al. 12-lipoxygenase metabolite 12 (S) -HETE stimulates human pancreatic cancer cell proliferation via protein tyrosine phosphorylation and ERK activation. Int J Cancer. 2001 Dec 1;94 (5) :630-6.|[2]Tang DG, et al. 12 (S) -HETE is a mitogenic factor for microvascular endothelial cells: its potential role in angiogenesis. Biochem Biophys Res Commun. 1995 Jun 15;211 (2) :462-8.