(R) -ND-336
(R) -ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R) -ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM) . (R) -ND-336 has the potential for diabetic foot ulcers (DFUs) research[1].
Product Specifications
CAS Number
[2252493-33-5]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/r-nd-336.html
Solubility
10 mM in DMSO
Smiles
NCC1=CC=C(OC2=CC=C(C=C2)S(C[C@@H]3SC3)(=O)=O)C=C1.Cl
Molecular Formula
C16H18ClNO3S2
Molecular Weight
371.90
References & Citations
[1]Trung T Nguyen, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018 Oct 11;61 (19) :8825-8837.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-14; MMP-2; MMP-9
Curated Selection
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