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JNJ-46356479

JNJ-46356479 is a selective and orally bioavailable mGlu2 receptor positive allosteric modulator (PAM), with the EC50 of 78 nM. JNJ-46356479 shows active in vivo[1].

Product Specifications

CAS Number

1254979-66-2

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-46356479.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C(F)=C1)N2CCN(CC2)CC3=C(C4=NN=C(N4C=C3)CC5CC5)C(F)(F)F

Molecular Formula

C22H22F5N5

Molecular Weight

451.44

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cid JM, et al. Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[ (4- (2,4-difluorophenyl) -1-piperazinyl) methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM) . J Med Chem. 2016;59 (18) :8495-8507.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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