NTRC-824

NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM) [1].

Product Specifications

CAS Number

[1623002-61-8]

UNSPSC

12352005

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ntrc-824.html

Purity

98.2

Smiles

CC(C)C[C@@H](C(O)=O)NC(CN1C=C(C(C(F)(F)F)=O)C2=C1C=CC(NS(=O)(C3=CC=C(C)C=C3)=O)=C2)=O

Molecular Formula

C25H26F3N3O6S

Molecular Weight

553.55

References & Citations

[1]Thomas JB, et al. Identification of N-[ (5-{[ (4-methylphenyl) sulfonyl]amino}-3- (trifluoroacetyl) -1H-indol-1-yl) acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2. J Med Chem. 2014 Sep 11;57 (17) :7472-7.