10-Formylfolic acid
10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].
Product Specifications
CAS Number
[134-05-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antifolate; Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/10-formylfolic-acid.html
Purity
94.49
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O
Molecular Formula
C20H19N7O7
Molecular Weight
469.41
Precautions
H302, H315, H319, H335
References & Citations
[1]M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71 (7) :2736-9.|[2]J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129 (7) :1315-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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