10-Formylfolic acid

10-Formylfolic acid is a potent inhibitor of dihydrofolate reductase. 10-Formylfolic acid be used as an early indicator of leukemia[1][2].

Product Specifications

CAS Number

[134-05-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antifolate; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/10-formylfolic-acid.html

Purity

94.49

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@@H](NC(C1=CC=C(N(C=O)CC2=NC3=C(N=C2)N=C(N)NC3=O)C=C1)=O)CCC(O)=O

Molecular Formula

C20H19N7O7

Molecular Weight

469.41

Precautions

H302, H315, H319, H335

References & Citations

[1]M D'Urso-Scott, et al. Formation of 10-Formylfolic Acid, a Potent Inhibitor of Dihydrofolate Reductase, in Rat Liver Slices Incubated with Folic Acid. Proc Natl Acad Sci U S A. 1974 Jul;71 (7) :2736-9.|[2]J E Baggott, et al. 10-Formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr. 1999 Jul;129 (7) :1315-8.