Tripolin A

Tripolin A ((E) -Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].

Product Specifications

CAS Number

[1148118-92-6]

Product Name Alternative

(E) -Tripolin A

UNSPSC

12352005

Target

Aurora Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tripolin-a.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(C=CC=C2)/C1=C\C3=CC(O)=CC=C3O

Molecular Formula

C15H11NO3

Molecular Weight

253.25

References & Citations

[1]Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8 (3) :e58485.