Tripolin A
Tripolin A ((E) -Tripolin A) is a specific non-ATP competitive Aurora A kinase inhibitor, with IC50 values of 1.5 μM and 7 μM for Aurora A and Aurora B, respectively[1].
Product Specifications
CAS Number
1148118-92-6
Product Name Alternative
(E) -Tripolin A
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tripolin-a.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC=C2)/C1=C\C3=CC(O)=CC=C3O
Molecular Formula
C15H11NO3
Molecular Weight
253.25
References & Citations
[1]Iliana A Kesisova, et al. Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules. PLoS One. 2013;8 (3) :e58485.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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