JNJ-54166060
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively[1].
Product Specifications
CAS Number
1627900-41-7
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jnj-54166060.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C(F)(F)F)=C1Cl)N2CCC3=C(N=CN3C4=NC=C(F)C=C4)[C@H]2C
Molecular Formula
C20H15ClF4N4O
Molecular Weight
438.81
References & Citations
[1]Devin M Swanson, et al. Identification of (R) - (2-Chloro-3- (trifluoromethyl) phenyl) (1- (5-fluoropyridin-2-yl) -4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5 (4H) -yl) methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem. 2016 Sep 22;59 (18) :8535-48.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2X7 Receptor
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