Sibenadet (hydrochloride)

Sibenadet hydrochloride (AR-C68397AA) is a dual D2 dopamine receptor, beta2-adrenoceptor agonist with bronchodilator activity. Investigation in animal models of key chronic obstructive pulmonary disease (COPD) symptoms has demonstrated that Sibenadet hydrochloride effectively inhibits sensory nerve activity, thereby reducing reflex cough, mucus production and tachypnoea.

Product Specifications

CAS Number

[154189-24-9]

Product Name Alternative

AR-C68397AA

UNSPSC

12352005

Target

Adrenergic Receptor; Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sibenadet-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1SC2=C(C=CC(O)=C2N1)CCNCCS(=O)(CCCOCCC3=CC=CC=C3)=O.[H]Cl

Molecular Formula

C22H29ClN2O5S2

Molecular Weight

501.06

References & Citations

[1]Ind PW, Laitinen L, Laursen L, et al. Early clinical investigation of Viozan (sibenadet HCl), a novel D2 dopamine receptor, beta2-adrenoceptor agonist for the treatment of chronic obstructive pulmonary disease symptoms. Respir Med. 2003;97 Suppl A:S9-S21.