Zgwatinib
Product Specifications
UNSPSC Description
Zgwatinib (SOMG-833) is a potent, selective, and ATP-competitive c-MET inhibitor, with an IC50 of 0.93 nM against c-MET, over 10,000-fold more potent compared with 19 tyrosine kinases (including c-MET family members and highly homologous kinases). Zgwatinib potently inhibits c-MET-driven cell proliferation. Zgwatinib as a potential candidate agent for c-MET-driven human cancers research[1].
Target Antigen
c-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zgwatinib.html
Solubility
10 mM in DMSO
Smiles
O=[N+]([O-])C1=CC(CNC2=C3C=C(C=NC3=CC(C(F)(F)F)=C2)N4CCN(CC4)C)=CC=C1
Molecular Weight
445.44
References & Citations
[1]Zhang, H, et al. SOMG-833, a Novel Selective c-MET Inhibitor, Blocks c-MET-Dependent Neoplastic Effects and Exerts Antitumor Activity. Journal of Pharmacology and Experimental Therapeutics, 350(1), 36–45.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124267/Zgwatinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124267/
Clinical Information
No Development Reported
CAS Number
1268264-10-3
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