AF-DX 384 (methanesulfonate)

AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (Kis=6.03 and 10 nM, respectively) [1]. AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine[2].

Product Specifications

CAS Number

[118290-27-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/af-dx-384-methanesulfonate.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C2=NC=CC=C2NC(C3=CC=CC=C31)=O)NCCN4C(CN(CCC)CCC)CCCC4.CS(=O)(O)=O

Molecular Formula

C28H42N6O5S

Molecular Weight

574.74

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Dörje F, et al. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther. 1991 Feb;256 (2) :727-33.|[2]Vannucchi MG, et al. Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats. Neuroscience. 1997 Aug;79 (3) :837-46.