JNJ-56022486

JNJ-56022486 is an orally active and potent negative AMPA receptor modulator (Ki=19 nM) selective for TARP-γ8. JNJ-56022486 is also a TARP-γ8 receptor antagonist, with blood brain barrier (BBB) permeability. JNJ-56022486 can be used for research of Epilepsy[1][2].

Product Specifications

CAS Number

[2036082-79-6]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jnj-56022486.html

Solubility

10 mM in DMSO

Smiles

N#CCC1=CC=CC(Cl)=C1C2=CC=C(N3)C(NC3=O)=C2

Molecular Formula

C15H10ClN3O

Molecular Weight

283.71

References & Citations

[1]Maher MP, et al. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357 (2) :394-414. |[2]Rosenbaum MI, et al. Targeting receptor complexes: a new dimension in drug discovery. Nat Rev Drug Discov. 2020 Dec;19 (12) :884-901.