Runx1-CBFβ interaction inhibitor 1
Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC50=3.2 μM) [1].
Product Specifications
CAS Number
[493028-20-9]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
RUNX
Type
Reference compound
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/runx1-cbfβ-interaction-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1C2=C(CC)SC(N)=N2
Molecular Formula
C12H14N2OS
Molecular Weight
234.32
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Michael J Gorczynski, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol. 2007 Oct;14 (10) :1186-97.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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