Runx1-CBFβ interaction inhibitor 1

Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC50=3.2 μM) [1].

Product Specifications

CAS Number

[493028-20-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

RUNX

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/runx1-cbfβ-interaction-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

COC(C=C1)=CC=C1C2=C(CC)SC(N)=N2

Molecular Formula

C12H14N2OS

Molecular Weight

234.32

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

References & Citations

[1]Michael J Gorczynski, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol. 2007 Oct;14 (10) :1186-97.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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