Aminooxy-PEG4-alcohol
Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Product Specifications
CAS Number
[106492-60-8]
UNSPSC
12352203
Hazard Statement
H302-H315-H318-H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aminooxy-peg4-alcohol.html
Solubility
10 mM in DMSO
Smiles
NOCCOCCOCCOCCO
Molecular Formula
C8H19NO5
Molecular Weight
209.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.|[2]Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb) . 2010 Dec 7;46 (45) :8651-3.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
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