Aminooxy-PEG4-alcohol

Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[106492-60-8]

UNSPSC

12352203

Hazard Statement

H302-H315-H318-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aminooxy-peg4-alcohol.html

Solubility

10 mM in DMSO

Smiles

NOCCOCCOCCOCCO

Molecular Formula

C8H19NO5

Molecular Weight

209.24

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Heather D. Maynard, et al. Method of creating hydrogels through oxime bond formation. US20150202305A1.|[2]Murray BS, et al. Reactive thermoresponsive copolymer scaffolds. Chem Commun (Camb) . 2010 Dec 7;46 (45) :8651-3.