LY 278584
LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a Ki of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors[1].
Product Specifications
CAS Number
[119193-37-2]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly-278584.html
Purity
90.0
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC(CCC2C1)N2C)C3=NN(C4=C3C=CC=C4)C
Molecular Formula
C17H22N4O
Molecular Weight
298.38
References & Citations
[1]D W Robertson, et al. Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N- (8-methyl-8-azabicyclo[3.2.1]oct-3-yl) -1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors. J Med Chem. 1990 Dec;33 (12) :3176-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; lactoferrin
Curated Selection
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