3-Hydroxyphenazepam

3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake[1].

Product Specifications

CAS Number

[70030-11-4]

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3-hydroxyphenazepam.html

Purity

99.90

Solubility

10 mM in DMSO

Smiles

BrC1=CC(C(C2=CC=CC=C2Cl)=NC3O)=C(C=C1)NC3=O

Molecular Formula

C15H10BrClN2O2

Molecular Weight

365.61

References & Citations

[1]Borisova T, et, al. GABAA receptor agonist cinazepam and its active metabolite 3-hydroxyphenazepam act differently at the presynaptic site. Eur Neuropsychopharmacol. 2021 Apr;45:39-51.