APHA Compound 8
Product Specifications
UNSPSC Description
APHA Compound 8 (Compound 4) is a histone deacetylase (HDAC) inhibitor. APHA Compound 8 has antimouse HDAC1 activity with an IC50 value of 0.78 μM. APHA Compound 8, as antiproliferative and cytodifferentiating agent on MEL cells, shows dose-dependent growth inhibition and hemoglobin accumulation effects[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/apha-compound-8.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C=C1/C=C/C(NO)=O)C(CC2=CC=CC=C2)=O
Molecular Weight
284.31
References & Citations
[1]Ragno R, et al. 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem. 2004 Mar 11;47(6):1351-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-124022/APHA-Compound-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-124022/
Clinical Information
No Development Reported
CAS Number
676599-90-9
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