HS56
HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and > 100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension[1].
Product Specifications
CAS Number
[922050-57-5]
UNSPSC
12352005
Target
DAPK; Pim
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hs56.html
Purity
99.6
Solubility
10 mM in DMSO
Smiles
N#CCSC1=NC(N(C2=CC=CC(Cl)=C2)N=C3)=C3C(N1)=O
Molecular Formula
C13H8ClN5OS
Molecular Weight
317.75
References & Citations
[1]Carlson DA, et, al. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 Oct 18;25 (10) :1195-1207.e32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1; PIM2; PIM3
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