Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

MPT0G211 (mesylate)

MPT0G211 mesylate is a potent, orally active and selective HDAC6 inhibitor (IC50=0.291 nM) . MPT0G211 mesylate displays >1000-fold selective for HDAC6 over other HDAC isoforms. MPT0G211 mesylate can penetrate the blood-brain barrier. MPT0G211 mesylate ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model. MPT0G211 mesylate has anti-metastatic and neuroprotective effects. Anticancer activities[1][2][3].

Product Specifications

CAS Number

2151854-33-8

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mpt0g211-mesylate.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(O)=O.O=C(NO)C1=CC=C(CNC2=C3N=CC=CC3=CC=C2)C=C1

Molecular Formula

C18H19N3O5S

Molecular Weight

389.43

References & Citations

[1]Fan SJ, et al. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model. Cell Death Dis. 2018;9 (6) :655. Published 2018 May 29.|[2]Hsieh YL, et al. Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo. Biochim Biophys Acta Mol Cell Res. 2019;1866 (6) :992-1003.|[3]Tu HJ, et al. The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells. Clin Epigenetics. 2018;10 (1) :162. Published 2018 Dec 29.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC6

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Amopyroquine
TRC-A634215-5MG 5 mg

Amopyroquine

Sign In for Pricing
View Details
Recombinant beta Catenin (phospho S33/S37) Antibody
RC-16372-01 50 μL

Recombinant beta Catenin (phospho S33/S37) Antibody

Sign In for Pricing
View Details
Recombinant beta Catenin (phospho S33/S37) Antibody
RC-16372-02 100 µL

Recombinant beta Catenin (phospho S33/S37) Antibody

Sign In for Pricing
View Details
Recombinant beta Catenin (phospho S33/S37) Antibody
RC-16372-03 1 mL

Recombinant beta Catenin (phospho S33/S37) Antibody

Sign In for Pricing
View Details
Sema5b Mouse Gene Knockout Kit (CRISPR)
KN515507 1 Kit

Sema5b Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details
Phospho-NF-kB p65 (S536) Recombinant Rabbit monoclonal Antibody
HA751361 100 µL

Phospho-NF-kB p65 (S536) Recombinant Rabbit monoclonal Antibody

Sign In for Pricing
View Details