Dothiepin
Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis[1].
Product Specifications
CAS Number
[113-53-1]
Product Name Alternative
Dosulepin; Dothep
UNSPSC
12352005
Hazard Statement
H302, H361, H362
Target
5-HT Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dothiepin.html
Purity
98.22
Solubility
10 mM in DMSO
Smiles
CN(C)CC/C=C1C2=CC=CC=C2SCC3=CC=CC=C/13
Molecular Formula
C19H21NS
Molecular Weight
295.44
Precautions
H302, H361, H362
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
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