MRK-623
MRK-623 (Compound 14k) is an orally active, high-affinity GABAA receptor agonist, with the Ki values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect[1].
Product Specifications
CAS Number
[461449-78-5]
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mrk-623.html
Purity
98.73
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CC(O)(C1=NC2=NC=C(C3=CC=C(F)C(C4=CC=CN=C4)=C3)N2C=C1)C
Molecular Formula
C20H17FN4O
Molecular Weight
348.37
References & Citations
[1]Simon C Goodacre, et al. Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA (A) alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. J Med Chem. 2006 Jan 12;49 (1) :35-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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