BIO7662
BIO7662 is a specific α4β1 antagonist. BIO7662 can be used to study α4β1 integrin-ligand interactions[1][2].
Product Specifications
CAS Number
327613-10-5
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bio7662.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@@H](NC([C@H]1N(S(=O)(C2=CC=CC=C2)=O)CCC1)=O)CCNC([C@@H](N(C)C(CC3=CC=C(NC(NC4=CC=CC=C4C)=O)C=C3)=O)CC(C)C)=O
Molecular Formula
C38H48N6O8S
Molecular Weight
748.89
References & Citations
[1]Egger LA, et al. A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence. J Pharmacol Exp Ther. 2003 Sep;306 (3) :903-13.|[2]Chen LL, et al. Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium. J Biol Chem. 2001 Sep 28;276 (39) :36520-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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