NSC745887

NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage[1][2].

Product Specifications

CAS Number

[54490-26-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc745887.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C2N=CC=NC2=C1C3=O)C4=C3C=CC=C4

Molecular Formula

C16H8N2O2

Molecular Weight

260.25

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17 (21) :7418-7428.|[2]Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9 (15) :11922-11937.