VT-1598 (tosylate)
Product Specifications
UNSPSC Description
VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris[1][2]. VT-1598 (tosylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/vt-1598-tosylate.html
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=S(O)(C1=CC=C(C=C1)C)=O.FC(F)(C2=CC=C(C=N2)C#CC3=CC=C(C=C3)OCC4=CC=C(C=C4)C#N)[C@@](O)(C5=C(C=C(C=C5)F)F)CN6C=NN=N6
Molecular Weight
756.72
References & Citations
[1]Nathan P Wiederhold, et al. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18.|[2]Timothy J Break, et al. VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. J Antimicrob Chemother. 2018 Aug 1;73(8):2089-2094.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123777A/VT-1598-tosylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123777A/
Clinical Information
Phase 1
CAS Number
2089321-00-4
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1054777-01 0.02 mg (E-Coli)
Recombinant Haemophilus influenzae 2-succinylbenzoate--CoA ligase (menE)
Ask
View Details MBS1054777-02 0.02 mg (Yeast)
Recombinant Haemophilus influenzae 2-succinylbenzoate--CoA ligase (menE)
Ask
View Details 
MBS1054777-03 0.1 mg (E-Coli)
Recombinant Haemophilus influenzae 2-succinylbenzoate--CoA ligase (menE)
Ask
View Details