EGFR-IN-99
EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
2068806-31-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-99.html
Purity
98.09
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4
Molecular Formula
C25H22FN7O3
Molecular Weight
487.49
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Jang J, et al. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 Sep 3;57 (36) :11629-11633.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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